Gene information
Official symbol ANGPT1
Official full name angiopoietin 1
Gene type protein-coding gene
Chromosome8q23.1
Alias symbolKIAA0003; Ang1
Gene familyReceptor ligands; Fibrinogen C domain containing
Resources
Entrez Gene 284
HGNC HGNC:484
Ensembl ENSG00000154188
Vega OTTHUMG00000164812
UCSC uc003ymn.4
GO terms: 91 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002698 negative regulation of immune effector process GO Biological Processes -11.7829906 16 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032835 glomerulus development GO Biological Processes -5.62617381 12 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043114 regulation of vascular permeability GO Biological Processes -8.20071376 14 More
GO:0043116 negative regulation of vascular permeability GO Biological Processes -3.15220350 5 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061437 renal system vasculature development GO Biological Processes -6.91942497 9 More
GO:0061440 kidney vasculature development GO Biological Processes -6.91942497 9 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072006 nephron development GO Biological Processes -8.44009723 23 More
GO:0072012 glomerulus vasculature development GO Biological Processes -7.35783353 9 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098858 actin-based cell projection GO Cellular Components -2.23189213 18 More
GO:1900180 regulation of protein localization to nucleus GO Biological Processes -3.85830967 16 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:1990782 protein tyrosine kinase binding GO Molecular Functions -4.10270724 15 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
trebananib inhibitor ChemblInteractions view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
angiopoietin-1 proteomics myocardial injury[prognosis (bad)] acute ST elevation myocardial infarction Chen S et al. Biomarkers. 2012
angiopoietin-1 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Liu KL et al. Int J Cardiol. 2015
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